The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. It is . Your file is uploaded and ready to be published. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. (1962). Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. 6 Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Synergies to simplify formulation challenges and reduce operational costs. : 9004-34-6 Date Approved: 01/31/2008 . It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. No. Avicel PH-101. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. P}MFbN#[>r(y (&E. Microcrystalline Cellulose as Pharmaceutical Excipient The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. EP1551879A4 - Production of microcrystalline cellulose - Google Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . <> Avicel RC 591 MSDS CasNo.51395-75-6 - lookchem.com . F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Buy Chemicals. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. gwf;J(e0o|1p{R~P^);ao!%{0KD7. <> CAS 9004-34-6. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Instead, they obtained a stable colloidal suspension. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. % The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. cas:9032-51-3 msds CELLULOSE PAB. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. PDF Microcrystalline Cellulose MSDS manufacturers Substance Information - ECHA - Europa The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Gloves, eye protection and a dust mask should be used. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? EMCOCEL - JRS Pharma Apply today! Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) endobj Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. %PDF-1.4 Powder becomes slippery when wet. Microcrystalline Cellulose; Cellulose; Functions. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). . Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. MATERIAL SAFETY DATA SHEET. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . PDF MATERIAL SAFETY DATA SHEET - Pfizer /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Product Name: Microcrystalline Cellulose 1.2. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Origin(s): Plant/Botanical. [FMC Study Number I92-1464]. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. endobj It is, however, a good source of fibre. SDS - Safety Data Sheet. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . << Validity Area. : 51395-75-6 Date Approved: 01/31/2008 Revision No. In 1964 FMC, Corporation . The aqueous solution to barrier membrane coating. It is a white, free-flowing powder. Cellulose microcrystalline for column chromatography. Microcrystalline Cellulose Market Size to Increase Significantly in Document(s): certificate data msds. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. MATERIAL SAFETY DATA SHEET - Sevron SUBSTANCE IDENTIFICATION 1.1. Microcrystalline Cellulose Market Forcast 2023 To 2028 : In-depth ). PDF PRODUCT OVERVIEW: Avicel RC-591 - Signet 1.3. CAS #: 9004-34-6 . TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Excipients for Pharmaceuticals | Products | IFF - DuPont Microcrystalline cellulose (cas 9004-34-6) SDS(Safety Data Sheet) /MSDS PDF Material Safety Data Sheet Well-recognized product that can do it all. All Rights Reserved. 9,LL!z Comprecel|MINGTAI CHEMICAL SUBSTANCE IDENTIFICATION 1.1. The table below shows the most common physicochemical parameters of this raw material. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Millipore. w !1AQaq"2B #3Rbr EMCOCEL 90 M. 130. ( Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Microcrystalline Cellulose Market Share, Trend, Statistics - 2031 Are you looking for information about products and services by region? The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. stream The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Microcrystalline Cellulose (MCC) MSDS 1. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. ChemicalBook. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. 2008-2023 ChemPoint. PDF (4.11 mb) Footer menu 1. Micro Crystalline Cellulose. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. 1 0 obj %PDF-1.3 < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Microcrystalline Cellulose MSDS - Newseed Chemical Co., Limited X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? MSDS Ref. SCMm_>x^O9l (n. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants.
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